From imaging babies to blasting apart kidney stones, ultrasound has proved to be a versatile tool for physicians. Now, several research teams aim to unleash the technology on some of the most feared brain diseases.The blood-brain barrier, a tightly packed layer of cells that lines the brain’s blood vessels, protects it from infections, toxins, and other threats but makes the organ frustratingly hard to treat. A strategy that combines ultrasound with microscopic blood-borne bubbles can briefly open the barrier, in theory giving drugs or the immune system access to the brain. In the clinic and the lab, that promise is being evaluated.This month, in one of the first clinical tests, Todd Mainprize, a neurosurgeon at the University of Toronto in Canada, hopes to use ultrasound to deliver a dose of chemotherapy to a malignant brain tumor. And in some of the most dramatic evidence of the technique’s potential, a research team reports this week in Science Translational Medicine that they used it to rid mice of abnormal brain clumps similar to those in Alzheimer’s disease, restoring lost memory and cognitive functions. If such findings can be translated from mice to humans, “it will revolutionize the way we treat brain disease,” says biophysicist Kullervo Hynynen of the Sunnybrook Research Institute in Toronto, who originated the ultrasound method.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Some scientists stress that rodent findings can be hard to translate to humans and caution that there are safety concerns about zapping the brain with even the low-intensity ultrasound used in the new study, which is similar to that used in diagnostic scans. Opening up the blood-brain barrier just enough to get a beneficial effect without scorching tissue, triggering an excessive immune reaction, or causing hemorrhage is the “crux,” says Brian Bacskai, a neurologist at Massachusetts General Hospital in Boston who studies Alzheimer’s disease and used to work with Hynynen.Safely and temporarily opening the blood-brain barrier is a long-sought goal in medicine. About a decade ago, Hynynen began exploring a strategy combining ultrasound and microbubbles. The premise is that ultrasound causes such bubbles to expand and contract, jostling the cells forming the blood-brain barrier and making it slightly leaky. That could help cancer physicians such as Mainprize deliver chemotherapy drugs into the brain. Hynynen also hypothesized that the brief leakage would rev up the brain’s inflammatory response against β amyloid—the toxic protein that clumps outside neurons in Alzheimer’s and may be responsible for killing them. Disposing of such debris is normally the role of the microglia, a type of brain cell. But previous studies have shown that when β amyloid forms clumps in the brain, it “seems to overwhelm microglia,” Bacskai says. Exposing the cells to anti bodies that leak in when the blood-brain barrier is breached could spur them to “wake up and do their jobs,” he says. Some antibodies in blood may also bind directly to the β-amyloid protein and flag the clumps for destruction.Hynynen and others have recently tested the ultrasound strategy in a mouse model of Alzheimer’s. In December 2014, for example, he and colleagues reported in Radiology that the method reduces amyloid plaques in a strain of mice engineered to develop the deposits, leading to improvements in cognition and spatial learning. Microglia consumed more β amyloid after the treatment, suggesting the cells do play a role in the effect, says neuroscientist Isabelle Aubert, who collaborates with Hynynen at Sunnybrook.This week, neuroscientist Jürgen Götz of the Queensland Brain Institute in St. Lucia, Australia, and his Ph.D. student Gerhard Leinenga report that they have built on Hynynen and Aubert’s protocol, using a different mouse model of Alzheimer’s. After injecting these animals with a solution of microscopic bubbles, they scanned an ultrasound beam in a zigzag pattern across each animal’s entire skull, rather than focusing on discrete areas as others have done. After six to eight weekly treatments, the team tested the rodents on three different memory tasks. Alzheimer’s mice in the control group, which received microbubble injections but no stimulation, showed no improvement. Mice whose blood-brain barriers had been made permeable, in contrast, saw “full restoration of memory in all three tasks,” Götz says.The team also found a two- to fivefold reduction in different types of β-amyloid plaques in the brain tissue of the treated group. The attempt to stoke microglia’s appetite appeared to work; Götz and Leinenga found much more β-amyloid protein within the trash-eating cells of treated animals. Yet rousing microglia may not be the only mechanism responsible for the rodents’ memory boost, Aubert notes. She and Hynynen recently reported in Brain Stimulation that ultrasound also boosts the birth and growth of new neurons in mice.Götz and Leinenga next plan to test the whole-brain ultrasound scan method in larger animals with β-amyloid deposits, such as sheep. The approach, which could in theory be used for other brain diseases involving abnormal protein clumps, “is exciting,” says Gerald Grant, a neurosurgeon at the Stanford University School of Medicine in Palo Alto, California. “We’ve been thinking of opening up the blood-brain barrier as a way to get things into the brain, but this pays attention to getting things out.”It’s far from settled that eliminating β-amyloid deposits outside of neurons is the key to treating or stopping Alzheimer’s disease, however. And Bacskai is skeptical that the mouse results say much about the technique’s potential in humans. The range between a mouse that can learn and one that cannot learn “is pretty small,” so big gains in behavioral tests in mice may mean nothing in humans, he says. He adds that nonstandardized ultrasound equipment makes it hard to answer basic safety questions: “How long is the blood-brain barrier open? How big are the pores? What’s the damage?”Hynynen, who is working with a medical imaging company to commercialize the technique, notes that ultrasound application to the brains of animals including rabbits and monkeys has produced no negative side effects. And Mainprize’s clinical trial may provide more safety data. He hopes to open the blood-barrier to increase chemotherapy delivery to a brain cancer patient just before he operates to remove the tumor. Using Hynynen’s technology, he and colleagues will apply ultrasound and microbubbles to tissue in and around the tumor, as well as to several unaffected brain areas. Then they’ll examine excised tissue for hemorrhages and to see if the treatment boosted the concentration of the drug. A similar trial is now recruiting participants in France.If these phase I trials establish safety, “it opens the door for phase II trials looking to see if there’s any benefit” to opening the blood-brain barrier, including for conditions beyond cancer, Mainprize says. Despite his doubts, Bacskai can’t fully resist the dream driving this fledging field. “Imagine if your grandmother went to the clinic once per year, and it cleared amyloid β and that was all it took—no surgery, no drugs. It would be amazing.” EMMANUEL THÉVENOT/LAB OF ISABELLE AUBERT; COURTESY OF SUNNYBROOK RESEARCH INSTITUTE
A national survey of Asian Americans reveals that Indian Americans have all but slammed the door on the Republican Party.The National Asian American Survey (NAAS) found that Indian Americans favor Pres. Barack Obama over Republican nominee Mitt Romney 68% to 5%, with 25% presently undecided. It reported that 93% of Indians voted for Obama in 2008, a proportion only nominally lower than his support among African Americans. Half of Indian Americans identified themselves as Democrats and just 3% as Republicans, with the remaining listing themselves as Independents.At a time when Pres. Obama’s approval ratings have tanked, 81% of Indians approved of Pres. Obama’s job performance while 88% had a favorable impression of him, which is the highest of any ethnic group in the country and matches African American approval ratings of Obama.The precipitous decline of the GOP among Indian Americans is difficult to reconcile, because in many ways it is a logical constituency for Republican conservative doctrine. It is the most affluent ethnic group in the country and most Indians are socially and economically conservative. Indian Americans have not experienced the frontal brunt of the GOP’s hostile policies toward immigrants and minorities. Yet, Democrats enjoy far stronger support among Indian Americans than they do, for example, among Hispanics, who are significantly more impacted by the GOP’s uncompromising stance on immigration and welfare.The takeover of the Republican Party by right wing Christian fanatics and loony Tea Partiers, whose antipathy toward immigrants and minorities has driven out even mildly centrist Republicans, has turned off the few Indians who might have related with the party’s conservative ideology.It is not lost on the community that the two most successful Indian American Republicans — Gov. Bobby Jindal of Louisiana and Gov. Nikki Haley of South Carolina — succeeded only by eschewing their Indian identity and indeed even their religion. Their conversion from Hinduism and Sikhism to Christianity may well have been personal rather than motivated by political expediency; we don’t really know. What Indian Americans do know is that the Republican Party has no place for non-Christians. Even though Jindal and Haley were trotted out at the GOP Convention as minority ornaments to camouflage the party’s toxic anti-immigrant and anti-minority platform, it is patently clear that neither of them has any standing in the Indian American community.The NAAS survey discredits the mythology that a handful of heavyweight Indian American donors have created about a shift in the community toward the GOP. In the absence of polling data specific to the community, the deception was peddled successfully to naïve mainstream reporters and news starved ethnic media outlets. The NAAS report conclusively demonstrates that the self-appointed fat cat community leaders and spokesmen are completely detached from the people they profess to represent.Destabilizing international events and economic disruptions may yet propel Romney into the White House, although public opinion polls presently show him trailing badly, notwithstanding the fact that many of Pres. Obama’s supporters are disheartened by his timidity and failures in leadership during the first two years of his presidency.Regardless of how the 2012 election swings, however, it will mark the swan song of the angry white male, which is riding the GOP rough herd into the sunset. The demographics of the United States are marching inexorably against the hostage-takers of the Republican Party. The fundamentalist Right is so virulent, because it is so scared. It ought to be. Related Items
LATEST STORIES Kammuri turning to super typhoon less likely but possible — Pagasa Trending Articles PLAY LIST 00:50Trending Articles00:50Trending Articles01:30’Excited’ Terrence Romeo out to cherish first PBA finals appearance01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games “I can’t think about the last five games we played. I’m thinking about the sixth game that’s coming up. That’s all I can think about. One game at a time. This loss hurts, but it is what it is and we got to bounce back,” he said. View comments SEA Games in Calabarzon safe, secure – Solcom chief Don’t miss out on the latest news and information. Read Next Catriona Gray spends Thanksgiving by preparing meals for people with illnesses SMB coach Leo Austria continued to thread the needle with prized big man June Mar Fajardo as the veteran mentor keeping the three-time PBA Most Valuable Player on minutes restriction to give him time to recover from his calf injury while also keeping him fresh for the bigger wars ahead.But with Fajardo out, San Miguel suffered another close shave, this time losing to surprise contender NLEX, 103-100, on Sunday.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutLassiter, though, remains upbeat knowing that the Beermen have enough talent to win.“We got enough talent to beat teams, and every one from the bench can compete with anybody. We know we can compete at a high level so we just got to continue playing San Miguel ball and make sure that whoever’s out there, we’ll come out and play hard,” he said. Hamilton wins Belgian GP to trim Vettel’s lead to 7 points “Once we get fully healthy, we’ll be a different team and right now, we’re still finding our way, but I’m proud of the team that we gave our full effort. We just need to focus on certain areas that we want and don’t fall on the same stuff in the next one.”But for the Fil-Am sniper, he doesn’t want San Miguel to fall on the trap of playing the waiting game, saying that his team must find a way to rectify its miscues this early than feel sorry in the future.“We just got to get better at the things that we make mistakes on and learn from them,” he said, highlighting the poor start that saw the Beermen trail by 15 early, 25-10.“Of course, you want to play the full 48 minutes and that’s the key. If we could play the full 48 minutes, we could set the tone and play our style of brand. We can’t play two quarters, two-and-a-half, three-and-a-half, we got to play four quarters. That’s the key of beating any team. We can’t to come out and be down. We got to play the full four quarters.”And it starts in practice as San Miguel eyes to bounce back against Alaska on Saturday in Angeles City in Pampanga.ADVERTISEMENT MOST READ UPLB exempted from SEA Games class suspension WATCH: Streetboys show off slick dance moves in Vhong Navarro’s wedding Marcio Lassiter. Photo by Tristan Tamayo/ INQUIRER.netMarcio Lassiter will be the first to admit that right now, San Miguel is not the same team that won the first two championships this season.“It’s just different for us right now. We’re not used to playing this type of lineup all the time,” he said.ADVERTISEMENT Typhoon Kammuri accelerates, gains strength en route to PH Brace for potentially devastating typhoon approaching PH – NDRRMC LOOK: Venues for 2019 SEA Games
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India suffered a 2-0 defeat in their second Group A match of AFC Asian Cup 2019 against the United Arab Emirates at the Zayed Sports City Stadium in Abu Dhabi on Thursday.Goals from Ali Mabkhout and Khalfan Mubarak in the 41st and the 88th minute helped the hosts register their first win of the tournament after a 1-1 draw against Bahrain in the tournament opener on Saturday.India were clinical in front of goal during their impressive 4-1 win over Thailand on Sunday but their finishing was far from impressive earlier in the day against higher-ranked UAE, who walked away with three points.India have now slipped to the second spot of the Group A table while the hosts, who were cheered on by more than a 40,000-strong crowd in Abu Dhabi topped the group.As many as three chances went begging in the first half. Ashique Kurniyan’s left-footed effort and Sunil Chhetri’s header from a brilliant cross from Sunil Chettri was kept away by UAE goalkeeper, Khalid Essa who was brilliant throughout the match.UAE put early pressure on India by creating a few chances in the opening minutes of the match but India quickly managed to organise themselves and find their feet.Not our day as the #BlueTigers suffer a 2-0 defeat at the hands of UAE and as a result, we remain with 3 points after our first 2 games.#INDUAE #BackTheBlue #IndianFootball #AsianDream: AFC Media pic.twitter.com/JZFwh2YiIeIndian Football Team (@IndianFootball) January 10, 2019Three huge chances went begging but credit should go to UAE goalkeeper Khalid Essa who dnied Ashique Kuruniyan and Sunil Chhetri in the first half. Chhetri rued the missed chance as he was unmarked at the far post when Anirudh Thapa swung it in nicely only to see his captain head it straight into the body of Essa.advertisementIndia continued to be impressive in the mid-field as well but their finishing boots were missing on the big day. They paid the price for it when Mubarak scored his first international goal to give the hosts the lead just break the half-time break.Entering the game after a 1-1 stalemate with Bahrain, UAE required full points full points, and the relief was palpable in their camp when Mubarak broke the deadlock.The joy would have been short-lived for the home team had the talismanic Chhetri’s attempt not missed the target by a whisker in the 43rd minute, this after the Indian captain had the UAE defenders in splits and managed to cut one through one of the gaps with Eisa noweher in the picture.Down by a goal at the break, India were not to be disheartened and made their intentions clear in the second half.Constantine brought in Jeje Lalpekhlua in place of Halicharan Narzary and the Mizo forward, who scored two minutes after coming off the bench in the 4-1 mauling of Thailand, nearly did an encore in the 53rd minute. Jeje’s volley went inches off the post.Three minutes later, India again experienced the so-near-yet-so-far moment when Udanta Singh’s shot ricochets off the bar. UAE got their act together and troubled the Indians occasionally and they also had one of their attempts blocked by the bar.We are ready to fight against Bahrain: Chhetri”It was a tight game. UAE are a good side, and they converted their chances. When you get your chances, you got to convert them. If we could have taken ours, it could have been different. We are still in the running. As a team, we are united and we are ready to fight, and that’s what we are going to do against Bahrain,” Chhetri said.India knew that they had a tough task in hand against the United Arab Emirates (UAE), who were not only the better-ranked team than them but also had the huge home support from the crowd.UAE are ranked 79th in the FIFA rankings while India are positioned at 97th. Even in Asia, India (ranked 15th) are seven places below UAE (ranked 8th). More than the battle of the quality of football and the skills, it was always going to be about the physicality.Against Thailand, India had shown no nerves early on in the match and only because Thailand failed to make the best of their opportunities, India stayed in the fight and eventually toppled their opponents.Also Read | Thibaut Courtois joins Real Madrid’s long list of injured playersAlso Read | Sunil Chhetri’s team donates fines worth Rs 50,000 to Indian Blind Football FederationAlso See: India go down 0-2 to UAEadvertisement
UNIVERSITY PARK, PA – SEPTEMBER 30: Ayron Monroe #23 of the Penn State Nittany Lions waves to the crowd as he runs out for the game against the Indiana Hoosiers on September 30, 2017 at Beaver Stadium in University Park, Pennsylvania. Penn State defeats Indiana 45-14. (Photo by Brett Carlsen/Getty Images)ESPN’s Football Power Index has released its projections for every game on Penn State’s regular season schedule. Compared to some other metrics, the FPI is pretty bullish on the Nittany Lions.PSU has one glaring question on offense. Trace McSorley, perhaps the best quarterback in the program’s history, has graduated, and is now a Baltimore Raven.Sean Clifford, a talented but inexperienced quarterback, is expected to take over for him. The season may hinge on his ability to lead the offense.ESPN’s FPI has a full season projection of 8.9-3.2 for Penn State football in 2019, and ranks the team 12th.That is one spot ahead of Big Ten East power Ohio State.The game-by-game projections line up with that number as well. Penn State is the underdog, per FPI, in just three games this year, though it has at least a 41-percent chance in every game.Here are the full projected results:Week 1 vs. Idaho: WinWeek 2 vs. Buffalo: WinWeek 3 vs. Pitt: WinWeek 5 at Maryland: WinWeek 6 vs. Purdue: WinWeek 7 at Iowa: WinWeek 8 vs. Michigan: LossWeek 9 at Michigan State: LossWeek 11 at Minnesota: WinWeek 12 vs. Indiana: WinWeek 13 at Ohio State: LossWeek 14 vs. Rutgers: WinGiven the recruiting talent that Franklin is bringing in, a 9-3 season during a quarterback transition year would be a solid accomplishment.[ESPN]
India Today Web Desk New DelhiMarch 26, 2019UPDATED: March 26, 2019 12:54 IST IPL 2019: R Ashwin mankaded Jos Buttler during Kings XI Punjab’s win over Rajasthan Royals on Monday (IPL Photo)HIGHLIGHTSJos Buttler became the first batsman to be mankaded in IPL cricket on MondayR Ashwin has been facing criticism for mankading Jos Buttler during KXIP’s IPL 2019 openerIndia’s Vinoo Mankad was among the earliest to run a batsman out before delivering at the non-striker’s endJos Buttler’s run out during Rajasthan Royals’ home match against Kings XI Punjab on Monday was the first instance of a batsman being mankaded in the Indian Premier League (IPL).Buttler was run out at the non-striker’s end by Kings XI captain R Ashwin who claimed the Royals opener had left his crease before he could even load up into delivering the sixth ball of the 13th over of Royals’ 185-run chase in Jaipur.Ashwin immediately appealed for the wicket and the third umpire was called into play even as the Kings XI skipper and Buttler had a heated exchange mid-pitch. Eventually, Buttler was given out, prompting mixed reactions from former cricketers and experts on social media.If you’re wondering what’s all the fuss about mankading, here’s your guide to what has been one of the most controversial laws in the game of cricket.Mankading can come into play in situations where the batsman at the non-striker’s end leaves the crease before the bowler completes his delivery stride (or before the ball leaves the bowler’s hand). Batsmen, especially in limited-overs cricket, back up (or leave the crease at the non-striker’s end) in order to have momentum when the striker calls for a run.Marylebone Cricket Club (MCC), which takes care of the Laws of Cricket, in its rulebook states that a “bowler is permitted to attempt a run out” when the non-striker leaves his/her ground early.The 41.16 Law: Non-striker leaving his/her ground early”If the non-striker is out of his/her ground from the moment the ball comes into play to the instant when the bowler would normally have been expected to release the ball, the bowler is permitted to attempt to run him/her out. Whether the attempt is successful or not, the ball shall not count as one in the over. If the bowler fails in an attempt to run out the non-striker, the umpire shall call and signal Dead ball as soon as possible.”Crucial modification to the law in 2017advertisementThe MCC had made corrections and clarifications to the controversial mankad rule in 2017, giving the bowlers more leeway to run batsmen out at the non-striker’s end.Under the previous rule bowlers could attempt a run out only before entering their delivery stride. After the rule change, bowlers are allowed to run-out the batsman at the non-striker’s end up to the instant at which they “would be expected to deliver the ball”.”… the Law emphasises the importance of the non-striker remaining in his/her ground until the ball is released, which is felt to be important. With TV now potentially ruling that a batsman has made his/her ground by millimetres, it seems wrong to allow them a head-start of sometimes several feet in setting off. So, the policy in the Law has not been changed but rather the,” an explainer on “slight change” to Law 41.16 reads.Vinoo Mankad’s Mankad and Don Bradman’s reactionIndia’s Vinoo Mankad, after whom the rule is named, was among the earliest bowlers to run a non-striker out. During India’s tour of Australia on 13 December 1947, Mankad had run out Bill Brown when Brown had left the crease before he delivered the ball.Mankad faced a lot of criticism back then from the Australian media but legendary Australian player and the then Australia captain, Don Bradman had defended the India player.”An early sensation came in Australia’s innings when Brown was once more run out by Mankad, who, in the act of delivering the ball, held on to it and whipped the bails off with Brown well out of his crease,” Bradman said, as quoted by news.com.au.”This had happened in the Indian match against Queensland, and immediately in some quarters Mankad’s sportsmanship was questioned.””For the life of me I cannot understand why. The laws of cricket make it quite clear that the non-striker must keep within his ground until the ball has been delivered.R Ashwin defends Buttler MankadComing back to the recent incident in IPL, R Ashwin has been facing a lot of heat after he mankaded Buttler but the India off-spinner is not perturbed by the critical reactions.”It was pretty instinctive. I actually didn’t load and he (Buttler) left the crease,” Ashwin said at the post-match presentation ceremony on Monday.”That’s always been my take on it because it’s my half of the crease. I was not even at the crease, he wasn’t even looking at me and he just left the place,” Ashwin said.advertisementReacting to the incident, Rajasthan Royals coach Paddy Upton said the team will leave it to the fans to judge Ashwin.”Ashwin’s actions represent him. When I looked into the eyes of his teammates, I’m not sure it represented his teammates. I think we will leave it up to the IPL fans to decide if that’s the kind of thing they want to see. We’ll leave it up to the cricket world to judge R Ashwin’s actions tonight. For us, we are here to play cricket and entertain fans, be good role models for people who love the game,” Upton said.Also Read | https://www.indiatoday.in/sports/story/ravichandran-ashwin-mankad-controversy-rr-vs-kxip-ipl-2019-1486444-2019-03-26Also Read | England cricket stars slam R Ashwin after he Mankads Jos ButtlerAlso Read | Embarrassing and disgraceful: Shane Warne rants about R Ashwin’s mankading in IPL 2019Also See:For sports news, updates, live scores and cricket fixtures, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for Sports news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAkshay Ramesh Tags :Follow IPL 2019Follow Mankad controversyFollow R AshwinFollow Vinoo MankadFollow Rajasthan RoyalsFollow Jos ButtlerFollow Kings XI Punjab What is Mankading? All you need to know about the controversial cricket ruleR Ashwin has kicked up a storm after he mankaded Rajasthan Royals and England opener Jos Buttler in an Indian Premier League 2019 match on Monday. Here’s all that you need to know about mankading, which has been a controversial act over the years in the sportadvertisement
Rabat – The 28th Arab League Summit kicked off, Wednesday at the Dead Sea in Jordan, with the participation of several Kings, Emirs, Heads of State and Government and representatives of Arab countries.Moroccan Foreign Minister, Salaheddine Mezouar, takes part in the opening of this Summit, which will address several issues, notably the latest developments in the Palestinian question, the Arab peace initiative, the crises in Syria, Libya and Yemen, the fight against terrorism, refugee issues, and ways to strengthen and consolidate inter-Arab relations.The opening session will be marked by speeches, notably of President of the Islamic Republic of Mauritania (President of the 27th Arab League Summit), Mohamed Ould Abdel Aziz, King of Jordan, King Abdullah II Ibn Al Hussein (President of the current Summit), Secretary-General of the Arab League, Ahmed Aboul Gheit, UN Secretary-General, António Guterres, High Representative of the European Union for Foreign Affairs and Security Policy, Federica Mogherini, and Chairperson of the Commission of the African Union, Moussa Faki Mahamat.
“I didn’t find this decision reasonable,” Bergmann wrote. For one thing, he said, the application wasn’t that belated. Also, the authority’s decision didn’t even address the appellant’s stated reasons for the delay. And finally, there was no sign that the authority had even considered whether there might be grounds for examining his request, “given the fact that a rejection might, in some cases, send a man to his death.”The regulations governing asylum seekers state explicitly that if a request is filed more than a year after the applicant entered Israel, the request should be rejected out of hand. Nevertheless, they add, if the applicant cited special reasons for his belated application, his case should be considered by a designated border authority official.For many years, this time limit wasn’t enforced. But about a month ago, Haaretz reported that the authority had begun using it for the first time to reject asylum requests on the grounds that they were filed belatedly. A belated filing does constitute grounds for a more cursory examination of the request but not for rejecting it out of hand, Judge Dotan Bergmann wrote. An Israel court has slammed the country’s Interior Ministry on a case involving a Sri Lankan asylum seeker, haaretz reported.An appeals tribunal ruled that the Interior Ministry cannot simply reject asylum requests because they were filed belatedly. The appellant, a Sri Lankan national, entered Israel in September 2013 on a two-week tourist visa and never left. In May 2015, he filed an asylum request, saying he was being persecuted by criminals in his own country and feared they would kill him if he returned.About three weeks later, the border authority rejected his application on the grounds that it was filed more than a year after he entered Israel. He asked it to reconsider, saying the delay stemmed from a change of government in Sri Lanka, but the authority refused. The Tel Aviv tribunal said the ministry’s Population, Immigration and Border Authority must examine each asylum request on its merits, even if it was filed more than a year after the asylum seeker entered the country, as in the case before the court. As a result, it rejected almost all asylum applications by Eritrean and Sudanese migrants, even though they couldn’t have filed requests during their first year in the country because at that time Israel was granting them group protection, rather than letting them submit individual asylum requests. (Colombo Gazette)
by The Canadian Press Posted Aug 10, 2017 6:11 pm MDT Last Updated Aug 11, 2017 at 7:20 am MDT AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email Union takes over aerospace plant in Milton, Ont., to protest pension shortfalls MILTON, Ont. – The union representing workers at an aerospace plant in Milton, Ont., says its members have occupied the facility and stopped production in protest of pension cuts.Scott McIlmoyle, president of Unifor Local 112, says they entered the Northstar Aerospace west of Toronto at about 4 a.m. Thursday.He says the shutdown is in response to Northstar refusing to fund a 24 per cent shortfall in workers’ pensions at the plant.The union says the company has announced the relocation of the Milton facility’s equipment to Chicago and Windsor, Ont., but will not meet the pension shortfall for workers facing job loss.McIlmoyle says the company hasn’t budged in meetings on the subject and the pension shortfall means workers — both newly and soon-to-be retired — will receive about $200 less a month.Heligear Canada Acquisition Co. says in a statement that the pension was underfunded due to poor management before the company purchased the plant in 2012, and it does not control the pension design or its investments.“Heligear has made every payment required in its negotiated collective agreement with the union which also requires the company to make a final lump sum payment,” said Greg Harper, vice-president of human resources. “Heligear has not proposed any reduction of pension benefits. Any reduction or shortfall is a function of the plan management and design, which are not within Heligear’s control.”Harper said the company is pursuing legal remedies to recover control of the facility and resume production of vital products needed by its aerospace and defence customers.“Unifor bears responsibility for the current condition of the pension plan but refuses to acknowledge and accept that responsibility,” Harper said in a statement. “Unifor does not have a legal basis to hold Heligear responsible and its illegal action to seize control of the Milton facility is a desperate attempt to shift responsibility from Unifor to Heligear, through force, instead.”In a statement Thursday, Unifor national president Jerry Dias said the occupation of the plant is to send a message to the company that it “cannot short-change workers and the pension of retirees.”“There is no financial reason for refusing to fund the plan. The only excuse is corporate greed,” Dias said.The union said about 200 workers, union members and recent retirees were involved in the demonstration and about 150 of them had set up a picket line in front of the plant.The plant manufactures gears for Apache helicopters developed by Boeing Aerospace, along with other aerospace components.
Ohio State junior shortstop Kobie Foppe throws a ball during practice. Foppe is set to start at short in 2018 for the Buckeyes. Credit: Courtesy of Ohio State AthleticsThe Ohio State baseball team was dealt a blow after the end of the 2017 season when senior shortstop Jalen Washington graduated and left for professional baseball.The two-time captain was not only one of the most productive hitters for the team, but he also gave the Buckeyes a veteran dynamic it lacked.“I think the thing we’ll miss more than anything is his leadership and his presence in our clubhouse,” head coach Greg Beals said.One of the people tasked with helping replace him will be Kobie Foppe, a transfer from South Mountain Community College in Phoenix. It will not be easy.Washington was a versatile defender who could play both catcher and shortstop. He consistently hit in the top two positions of the lineup, tying for the team lead with both seven home runs and 14 stolen bases. He led the Buckeyes with 38 RBI and was the only player to appear in all 56 games.Foppe is set to be the team’s starting shortstop to open the season. Despite being touted as the 10th-best high-school prospect from Arizona in the 2014 class by baseball scouting service Perfect Game, Foppe went the junior college route.“I originally was gonna go to [Arizona State University] out of high school,” Foppe said. “Unfortunately there were a couple events that didn’t work out the way I would have wanted to, but going to South Mountain I think was actually probably better for me in turn.”Beals said he and his staff do their best to maintain connections with junior colleges in Arizona. Beals specifically reached out to his junior college contacts for a shortstop to add to the Buckeyes’ 2017 recruiting class.“We felt like that shortstop spot was somebody that we wanted to have some experience,” Beals said. “We felt like whomever was coming in needed to step in and play right away.”Foppe was identified as having the abilities Beals wanted. Then it became just a matter of convincing the Phoenix native that Columbus was the place for him.Foppe was sold on his visit.“I came on a gameday when they played Purdue. It was what they say, what they preach here, a brotherhood,” Foppe said. “That was really appealing to me and that ended up being a deciding factor.”In addition to a fielding style Beals termed “smooth,” Foppe has a vice grip on the mechanics required to play shortstop.“Just his instincts around the position,” Beals said. “The angles that he takes, just a real solid feel for baseball and a knack for being in the right spot.”Beals also is confident in the double-play combination created by Foppe and second baseman Brady Cherry.“They’re doing really well together,” Beals said. “Cherry has a lot of arm strength, which is usually not a characteristic of a second baseman, so that facilitates a good double-play turn.”Now that he’s earned his starting role, Foppe wants to improve his offensive consistency to help contribute to the batting order. He doesn’t expect to fully replace Washington in home run or RBI production, but Beals does not need that from him.“This lineup, while it may not have a [former Ohio State left fielder] Ronnie Dawson in it, I like the one through nine and the depth within this lineup,” Beals said. “The vision of this offense is to be really tough, and wear down a pitching staff because of the quality of the at-bat we’re gonna be able to give top to bottom.”Foppe’s debut with the Buckeyes occurs on Feb. 16 when the team opens the 2018 season in Port Charlotte, Florida, in the Snowbird Classic.
She said: “Being able to closely examine and conserve this painting for the first time in over 100 years has really given us the chance to get up-close and personal with the paintwork.”I noticed instantly that the painting bore a striking resemblance to the workshop of Botticelli himself. “Stylistically it was too similar to be an imitation, it was of the right period, it was technically correct and it was painted on poplar, a material commonly used at the time.”She added: “After removing the yellowing varnish, x-ray and infrared examination revealed under-drawing, including changes to the final composition uncommon in straight imitations.” The Botticelli Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily Front Page newsletter and new audio briefings. The discovery was made while the painting was being cleaned by conservatorsCredit:English Heritage It has been in the collection at a Georgian mansion for decades, admired by visitors as a clever imitation of a 15th century masterpiece.After closer inspection, which saw curators peel back at least a century’s worth of yellow varnish, a striking painting depicting the Madonna, Child and four angels has been assessed as a real work by Botticelli.The work was thought to have been a small copy of Botticelli’s famous Madonna Of The Pomegranate, painted by a talented but unknown peer. But X-ray testing, infrared studies and pigment analysis have indicated that the painting, with its vivid reds, blues and golds, came from Botticelli’s own Florence workshop.Rachel Turnbull, English Heritage’s senior collections conservator, said that after consulting with experts at the Victoria & Albert Museum and the National Gallery, “we are finally able to confirm that Madonna Of The Pomegranate is from the Florentine workshop of master painter Sandro Botticelli”.
A heated argument ended deadly on Sunday afternoon when a woman armed herself with a knife and stabbed her reputed husband to death at their Plaisance, East Coast Demerara (ECD) home.Victor Roberts, 38, of Lot 41 Prince Williams Street, Plaisance ECD was stabbed once to his chest by the suspect who was identified only as ‘Melissa’.The suspects being led out of the yard by an investigatorThe couple was heard arguing moments before the heinous crime was committed. According to reports, it has become a custom for the two people to fight with each other.Persons who gathered at the scene however, stated that this is the second time the now dead man was attacked and stabbed by the woman.When <
The Victorian Government is urging members of the Greek community to have their say on multiculturalism in Victoria. Minister for Multicultural Affairs and Citizenship Nicholas Kotsiras has called for nominations for the Multicultural Regional Advisory Councils across the state and invited Victorians to attend a Strengthening Our Community information session. “The Strengthening Our Community sessions provide an opportunity to inform Victorians about the Victorian Government’s work in developing new state-wide multicultural Regional Advisory Councils,” Kotsiras said. “The eight Regional Advisory Councils to be established across Victoria will act as vital links to the Victorian Multicultural Commission (VMC),” Kotsiras said. The core functions of the Regional Advisory Councils (RAC) will include: providing advice on settlement issues in the region, local multicultural affairs and citizenship; assisting the VMC to promote the benefits of cultural and religious diversity; advocating for culturally and linguistically diverse communities (CALD); and providing advice on communication, engagement and consultation with CALD communities. The government is looking for people who can express the interests of those in their community to consider becoming a member of a RAC. “We will be hosting forums across the state for open discussion on the Government’s plan for a multicultural Victoria,” Kotsiras said. “I encourage readers of Neos Kosmos to attend the forums which are being held in metropolitan and regional areas,” he added. The eight councils will operate in regional and metropolitan regions. For more information on the nomination process and attendance at information sessions, call the VMC on (03) 9651 0651, email email@example.com or visit multicultural.vic.gov.au Facebook Twitter: @NeosKosmos Instagram
Greek Finance Minister Yanis Varoufakis has said he and his wife came under attack by anarchists while dining in a central Athens restaurant.In a statement Wednesday, Varoufakis said he and his wife were in the Exarchia district, a neighbourhood popular with extreme leftists and anarchists, Tuesday night when a group barged into the restaurant.The group, who had their faces covered, demanded the minister leave the area and threw glass objects at the couple, Varoufakis said, without either of them being hurt.He said that when some of the group moved in a threatening manner against him, his wife embraced him so that the potential attackers could not get at him without hitting her first.Varoufakis eventually spoke with the group outside the restaurant, he said, and tempers were calmed. Source: AP Facebook Twitter: @NeosKosmos Instagram
Les Nike Hyperdunk allient technologie et sportAprès Adidas, c’est au tour de Nike de sortir des baskets intelligentes.Les Hyperdunk de Nike permettent de mesurer la vitesse, la détente et l’activité sportive du porteur. Déjà depuis 2006, avec Nike+iPod, disponible sur les appareils Apple, il est possible d’afficher ses performances sportives, notamment grâce au podomètre et à un capteur fixé dans une chaussure.Mais cette fois, Nike veut aller plus loin et rejoindre Adidas avec sa basket Nike Hyperdunk. En effet, Nike vient de créer une paire de chaussure, chacune équipée d’un capteur de mouvements. Chaque semelle est équipée de quatre zones de pression permettant de déterminer le mouvement exécuté et le synchronisme du sportif. À la fin de l’utilisation, l’athlète peut charger les données recueillies en synchronisant sa basket sur son ordinateur et analyser ses performances. Pour l’instant, la technologie n’est développé que sur les chaussures des basketteurs. Les baskets Nike Hyperdunk seront disponibles le 29 juin prochain pour 250 dollars (185 euros) et vous pourrez les voir en action aux pieds de Lebron James lors des Jeux Olympiques 2012 à Londres. Le 4 mars 2012 à 12:45 • Maxime Lambert
Causes de la dyslexie : et si le cerveau avait un problème de connexion ?Selon une recherche tout juste publiée, la dyslexie serait due à une mauvaise connectivité entre deux régions du cerveau. Cette découverte pourrait ouvrir la voie à de nouvelles formes de traitement.La dyslexie est un trouble qui se traduit notamment par une difficulté à lire et à saisir correctement le langage. On estime que 10% de la population mondiale est affectée par ce trouble neurologique. Jusqu’ici, cette pathologie était attribuée à une représentation mentale défectueuse des mots (notamment des phonèmes, les éléments sonores distinctifs du langage), comme l’explique Bart Boets, un psychologue belge. Mais ce clinicien de l’Université catholique de Louvain a décidé d’aller plus loin pour comprendre les mécanismes impliqués. Il a ainsi mené une étude auprès de 45 étudiants âgés de 19 à 32 ans, dont 23 étaient sérieusement dyslexiques. Les cerveaux des participants, tous de langue néerlandaise et droitiers, ont été observés par IRM tandis qu’ils écoutaient différentes séries de sons, par exemple “ba-ba-ba-ba” et “da-da-da-da”. Les sujets étaient alors chargés d’identifier ceux qui était différents.L’IRM a permis de dresser des images en 3D des cerveaux pendant l’écoute. Dans l’article publiée par la revue Science, Bart Boets explique que “de cette manière on peut obtenir une bonne signature neuronale des représentations phonétiques” des sons écoutés. Une fois l’expérience terminée, les chercheurs ont comparé les observations faites d’un individu à l’autre.Un temps de réponse plus lent Ils ont alors constaté que les réponses du groupe des dyslexiques et l’intensité de leurs réactions neuronales étaient similaires à celles du groupe témoin. “Leurs représentations phonétique mentales étaient parfaitement intactes”, souligne Bart Boets repris par l’AFP. Toutefois, la différence résidait dans le temps de réaction, les participants dyslexiques étant environ 50% plus lents à répondre. Après avoir analysé l’ensemble de l’activité cérébrale des sujets, les scientifiques ont constaté que les dyslexiques avaient une moins grande coordination entre 13 régions du cerveau qui traitent les sons élémentaires et l’aire de Broca, une des principales zones responsables du traitement du langage. Par ailleurs, d’autres analyses ont permis de révéler que plus la coordination entre les aires cérébrales était faible, plus la réponse des participants était lente. D’après les auteurs, ceci démontre que la cause de la dyslexie n’est pas une mauvaise représentation mentale des phonèmes mais un problème au niveau de la zone du cerveau qui assure le traitement des sons. “Il s’agit de la recherche la plus concluante depuis cinq ans” sur la dyslexie, estime Frank Ramus, un expert de l’Ecole Normale Supérieure de Paris qui n’a pas participé à l’étude. Des preuves qui font débat “Si ces résultats sont confirmés, ils modifieront profondément notre compréhension de la dyslexie”, ajoute t-il dans un commentaire publié en parallèle des travaux. Néanmoins, tous les spécialistes ne partagent pas son enthousiasme. C’est le cas de Michael Merzenich, un neurologue de l’Université de Californie à San Francisco, qui remet en doute le fait que les activités neuronales mesurées dans l’étude représentent bien les différents phonèmes entendus.À lire aussiLe mariage aiderait à prévenir les risques de démence, mais pourquoi ? Même scepticisme chez Iris Berent, une linguiste de l’Université Northeastern repris par l’AFP. Cette experte estime que les différents sons utilisés dans cette étude étaient trop faciles à distinguer les uns des autres. Pour elle, les résultats auraient été plus parlants si les participants étaient parvenus à distinguer des sons plus subtils. Une affirmation rapidement contestée par Frank Ramus. Pour lui, même avec des différences plus subtils, “l’IRM aurait permis de voir si les dyslexiques avaient une représentation défectueuse” des phonèmes entendus.Vers un traitement efficace ? Pour aller plus loin, Bart Boets compte exploiter ces nouvelles données et prévoit de chercher un moyen de remédier à ces mauvaises connexions cérébrales, apparemment à l’origine de la dyslexie. Cela pourrait, à terme, déboucher sur un traitement. Par exemple, “il n’est pas inconcevable de recourir à une stimulation électrique non-invasive du cerveau pour rétablir la communication entre ces deux régions cérébrales”, estime t-il.Le 6 décembre 2013 à 18:24 • Maxime Lambert
Jordan Henderson believes that England can take inspiration from Leicester City’s miracle Premier League title victory heading into the World CupThe Three Lions are considered outsiders for glory in Russia this summer with a relatively young and inexperienced line-up with Gary Cahill being the only player to have more than 50 caps to his name.As such, expectations are relatively low for the supporters with many claiming that a quarter-final appearance should be considered a success.But Henderson believes an upset should not be ruled out and pointed out the Leicester side that went from odds starting at 5000/1 to win the English top division at the start of the 2015/16 season to eventually ending up as the champions.Crouch: Liverpool could beat Man United to Jadon Sancho Andrew Smyth – September 14, 2019 Peter Crouch wouldn’t be surprised to see Jadon Sancho end up at Liverpool one day instead of his long-term pursuers Manchester United.“You’ve got to go in with the mentality that we can go all the way, because we are good enough as a team,” he said, via FourFourTwo.“There have been a lot of upsets in sport. No disrespect but look at when Leicester won the Premier League. Not a lot of people would have said they could have done that.“That is just one instance. You’ve got to have belief in the group all the time and believe you can reach the heights,” said Henderson, speaking ahead of England’s friendly with Costa Rica on Thursday.Gareth Southgate’s side begin their World Cup campaign against Tunisia on June 18, before later facing Panama and Belgium in their other two group stage matches.
Church of God of Prophecy gets new Minister Recommended for you Bahamian man busted; Prosecutor unable to make smuggling case stick Related Items:bahamian, church of god of prophecy, comedy, david wallace, halleluiah boys, independence day, sheep toungue souse, will stubbs Facebook Twitter Google+LinkedInPinterestWhatsApp Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 11 Jun 2015 – The One Bahamas Association of the Turks and Caicos forges ahead with plans to commemorate Bahamian Independence in the Turks and Caicos, despite recent remarks that the events are not welcomed. A souse out is planned for the TCI Bank parking lot on Saturday, as the organization which last year donated to the HOPE Foundation for Autism Awareness gears up for a number of activities surrounding the July 10th 42nd birthday of independent Bahamas. The Souse Out will feature Bahamian favorites including Sheep Tongue Souse and starts as early at 6:30am, this Saturday. Also this weekend Bahamian comedians David Wallace and Will Stubbs will be on island for a Hallelujah Boys show at the Church of God of Prophecy in Five Cays; that happens on Saturday night. Johnny Kemp confirmed dead by Bahamas Consul in Jamaica
In a social media post from Governor Dunleavy: “In the coming days, I will review and scrutinize the budget passed by the Legislature and determine the best path forward, including options to accept the budget as passed, to veto the budget in its entirety, or to veto portions of the budget to better align expenditures and revenues. I am absolutely determined to address the budget issues that have haunted Alaska for years.” Prior to the vote on the operating budget the Senate voted deadlocked 10-10 on a vote of whether to rescind their action last week, when they voted down the full payout. Senate Bill 1002, proposed by the Senate as part of a compromise, which would have given Alaskans a reduced PFD, to allow a vote on the rest of the state’s operating budget, was defeated last week. Facebook0TwitterEmailPrintFriendly分享The Senate unanimously passed the Fiscal Year 2020 operating budget during a floor session on Monday. The Alaska House of Representatives passed the same operating budget on Sunday which does not include a PFD. Governor Mike Dunleavy has said lawmakers should follow a longstanding formula and pay a full dividend. Some lawmakers share his position. But there are legislators who contend the formula is unsustainable. House and Senate leaders expect the budget bill, HB 39, to be ready for Governor Mike Dunleavy’s review within three days. The vote averts a government shutdown and allows state services to continue with the next fiscal year beginning July 1. If the Legislature passed a reduced dividend and Dunleavy rejected it, such a scenario almost certainly prompt another special session. The current special session is set to end this Friday. Representative Ben Carpenter: “I think one way or another we are going to be paying a full PFD.”